DKKL1 Antibody

Code CSB-PA892450LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892450LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DKKL1 Polyclonal antibody
Uniprot No.
Target Names
DKKL1
Alternative Names
Cancer/testis antigen 34 antibody; CT34 antibody; dickkopf like 1 antibody; Dickkopf-like protein 1 antibody; DKKL1 antibody; DKKL1_HUMAN antibody; Protein soggy-1 antibody; SGY antibody; SGY-1 antibody; SGY1 antibody; soggy 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Dickkopf-like protein 1 protein (31-242AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DKKL1 Antibody (Product code: CSB-PA892450LA01HU) is Non-conjugated. For DKKL1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA892450LB01HU DKKL1 Antibody, HRP conjugated ELISA
FITC CSB-PA892450LC01HU DKKL1 Antibody, FITC conjugated
Biotin CSB-PA892450LD01HU DKKL1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Gene References into Functions
  1. DKKL was overexpressed in colorectal cancer tissue compared with healthy colon. DKKL expression positively correlated with colorectal cancer progression. PMID: 27635108
  2. previously unreported alternative splicing patterns in the genes ZNF419 and DKKL1 PMID: 27826023
  3. Findings suggest that Dkk-3 plays a role in the regulation of cell interactions during retinoic acid-induced neuronal differentiation; effect on apoptosis was also observed upon expression of the related protein Dkkl-1 PMID: 24909558
  4. DKKL1/Dkkl1 may play an important role in testicular development and spermatogenesis and may be an important factor in male infertility. PMID: 22817830
Subcellular Location
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
Tissue Specificity
More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.
Database Links

HGNC: 16528

OMIM: 605418

KEGG: hsa:27120

STRING: 9606.ENSP00000221498

UniGene: Hs.515855

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