DRAM1 Antibody

Code CSB-PA836675LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA836675LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DRAM1 Polyclonal antibody
Uniprot No.
Target Names
DRAM1
Alternative Names
DRAM1; DRAM; DNA damage-regulated autophagy modulator protein 1; Damage-regulated autophagy modulator
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DNA damage-regulated autophagy modulator protein 1 protein (50-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DRAM1 Antibody (Product code: CSB-PA836675LA01HU) is Non-conjugated. For DRAM1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA836675LB01HU DRAM1 Antibody, HRP conjugated ELISA
FITC CSB-PA836675LC01HU DRAM1 Antibody, FITC conjugated
Biotin CSB-PA836675LD01HU DRAM1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
Gene References into Functions
  1. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53-dependent apoptosis (PUMA) and autophagy (DRAM) gene occurred, modifying the ADR-induced cancer cell death in HG both in vitro and in vivo. PMID: 28893313
  2. Overexpression of full-length AIFM1 suppresses proliferation and induces apoptosis of HepG2 and Hep3B cells. Caspase 3 and DRAM are involved in full-length AIFM1-induced apoptosis in HepG2 and Hep3B cells. PMID: 29501488
  3. DRAM1 regulates apoptosis by inhibiting BAX degradation. PMID: 25633293
  4. DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide. PMID: 24922577
  5. Suggest that promoting DRAM-mediated autophagy together with PI3K/AKT inhibition might be more effective for autophagy-based therapy in hepatoma. PMID: 24556693
  6. DRAM is an important gene for the enhancement of p53-dependent apoptosis. PMID: 24133622
  7. DRAM1 affects autophagy through lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes. PMID: 23696801
  8. DRAM gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species PMID: 23832602
  9. DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV. PMID: 23658518
  10. these findings shed new light on the role of autophagy in GBM and reveal a novel function of the autophagy regulators DRAM1 and p62 in control of migration/invasion in cancer stem cells. PMID: 22525272
  11. Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression. PMID: 23337876
  12. p73-regulated DRAM-1 is functionally involved in neutrophil differentiation of acute promyelocytic leukemia cells. PMID: 22981223
  13. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines. PMID: 22082963
  14. Overexpression of DRAM induces VRK1 downregulation and the opposite effect was observed by its knockdown. PMID: 21386980
  15. Collectively therefore, these studies not only report a stress-induced regulator of autophagy but also highlight the relationship of DRAM and autophagy to p53 function and damage-induced programmed cell death. PMID: 16839881
  16. DRAM links autophagy to p53 and programmed cell death. PMID: 17102582
  17. identified FLJ11259/DRAM as a p53-inducible member of a novel family of transmembrane proteins. FLJ11259/DRAM may be an important modulator of p53 responses in diverse tumor types. PMID: 17397945
  18. DRAM is activated by p53 which is required for the ability of p53 to induce autophagy and is also critical for the ability of p53 to induce programmed cell death. PMID: 19556885
  19. c-Jun NH2-terminal kinase as a novel mediator of DRAM protein regulation in Ewing sarcoma cells PMID: 19706754

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Subcellular Location
Lysosome membrane; Multi-pass membrane protein.
Protein Families
DRAM/TMEM150 family
Database Links

HGNC: 25645

OMIM: 610776

KEGG: hsa:55332

STRING: 9606.ENSP00000258534

UniGene: Hs.525634

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