ELF1 Antibody

Code CSB-PA007596DSR2HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007596DSR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA007596DSR2HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ELF1 Polyclonal antibody
Uniprot No.
Target Names
ELF1
Alternative Names
E74 like factor 1 antibody; E74-like factor 1 antibody; ELF 1 antibody; ELF1 antibody; ELF1_HUMAN antibody; Ets domain transcription factor antibody; ETS related transcription factor Elf 1 antibody; ETS related transcription factor Elf1 antibody; ets-related transcription factor antibody; ETS-related transcription factor Elf-1 antibody; mElf 1 antibody; p70 antibody; Sts1 antibody; TRANSCRIPTION FACTOR ELF 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human ETS-related transcription factor Elf-1 protein (1-210AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
Gene References into Functions
  1. ELF1 binding occurs at both TERT promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS motifs in the TERT promoter region. PMID: 26553150
  2. ELF-1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation. PMID: 26643049
  3. Data suggest that Elf-1 may modulate breast cancer progression to some extent without having an impact on survival of breast cancer patients. PMID: 21811762
  4. Expression of FLI-1, ELF-1, and GABP activated the PF4 promoter in HepG2 cells. PMID: 21931859
  5. The expression of Elf-1 and survivin in non-small cell lung cancer is related to differentiation, lymphatic metastasis, clinical stage, and prognosis, and both are positively correlated with microvessel density. PMID: 20346215
  6. the results indicate that insufficient O-GlcNAc modification prevents Elf-1-mediated transcriptional repression and thereby upregulates Tollip gene expression in intestinal epithelial cells. PMID: 21867680
  7. through a genome-wide association in a Hong Kong Chinese cohort and replication in 2 other Asian populations, identified association of ELF1 with systemic lupus erythematosus PMID: 21044949
  8. The expression levels of both Elf-1 and VEGF were significantly related with tumor differentiation, lymphatic metastasis, clinical stage, and postoperative survival time in non-small cell lung cancer. PMID: 19624906
  9. ETS transcription factor ELF1 is an important positive regulator of MEIS1 expression PMID: 20600580
  10. transcriptional regulation of the LAT gene, including the discovery that the Ets transcription factor Elf-1 may play a central role in its expression PMID: 16464244
  11. These results provide new evidence that Elf-1 is involved in transcriptional activation of hPygo2. PMID: 18314487
  12. Elf-1 in combination with Sp1 and GABP reduced FcRgamma promoter activity. PMID: 18378679
  13. aberrantly increased PP2A in lupus T cells dephosphorylates Elf-1 at Thr-231, resulting in limited expression and binding of the 98 kDa Elf-1 form to the CD3zeta and FcRgamma promoters. PMID: 18714041
  14. Includes a comparison of MEF to ELF1. PMID: 10207087

Show More

Hide All

Subcellular Location
Nucleus.
Protein Families
ETS family
Tissue Specificity
In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, l
Database Links

HGNC: 3316

OMIM: 189973

KEGG: hsa:1997

STRING: 9606.ENSP00000239882

UniGene: Hs.135646

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*