ENTPD2 Antibody

Datasheet

Code	CSB-PA007691ESR2HU
Size	US$166
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Image	Western blot All lanes: ENTPD2antibody at 3.6μg/ml Lane 1: Human placenta tissue Lane 2: U87 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 54, 52, 49 kDa Observed band size: 54 kDa Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007691ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA007691ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ENTPD2 Polyclonal antibody

Uniprot No.

Q9Y5L3

Target Names

ENTPD2

Alternative Names

NTPDase 2 antibody; NTPDase2 antibody; CD39 antigen like 1 antibody; CD39 antigen-like 1 antibody; CD39 like1 antibody; CD39L1 antibody; CD39like1 antibody; ecto ATP diphosphohydrolase 2 antibody; ecto ATPase 2 antibody; ecto ATPDase 2 antibody; Ecto-ATP diphosphohydrolase 2 antibody; Ecto-ATPase 2 antibody; Ecto-ATPDase 2 antibody; ectoATPase 2 antibody; ectoATPDase 2 antibody; Ectonucleoside triphosphate diphosphohydrolase 2 antibody; ENTP2_HUMAN antibody; Entpd2 antibody; NTPDase 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 2 protein (28-268AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

Gene References into Functions

In oviducts, remarkably, ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2), with the ability to hydrolyze ATP to AMP, are expressed in ciliated epithelial cells but with different subcellular localization. PMID: 29273916
Hypoxia upregulates ENTPD2 through HIF-1alpha in hepatocellular carcinoma and subsequently leading to the accumulation of extracellular 5'-AMP, which maintains myeloid-derived suppressor cells undifferentiated. PMID: 28894087
NTPDase2 and -3 are ecto-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease. PMID: 28472257
the lack of ecto-nucleotidase activity exhibited by NTPDase2 beta and -2 gamma and the C399S mutant, as well as the large reduction of activity in the N443D mutant are due to alterations in the folding/maturation of these proteins PMID: 12888562
NTPDase2 preferentially hydrolyzes nucleoside triphosphates. PMID: 15496502
down-regulation in biliary cirrhosis PMID: 15651265
NTPDase2 has a role in portal fibroblast regulation of bile duct epithelium proliferation PMID: 15799977
Mutagenesis study indicate the importance of K62 located in CR1, K182 downstream of ACR3, and R155. Mutation of Asp at the six potential glycosylation sites showed the importance of N64 in CR1 and N443 in ACR5 in protein function and expression PMID: 17489562
The role of cysteine 26 in the catalytic activity of NTPDase-2 and as the target of p-chloromercuriphenylsulfonate (pCMPS), a sulfhydryl reagent and NTPDase-2 inhibitor, is reported. PMID: 18656957

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Subcellular Location

[Isoform Long]: Cell membrane; Multi-pass membrane protein.; [Isoform Short]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform gamma]: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

GDA1/CD39 NTPase family

Tissue Specificity

Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.

Database Links

HGNC: 3364

OMIM: 602012

KEGG: hsa:954

STRING: 9606.ENSP00000347213

UniGene: Hs.123036

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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