EXTL2 Antibody

Code CSB-PA007903GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
EXTL2
Alternative Names
4-N-acetylhexosaminyltransferase EXTL2 antibody; Alpha 1 4 N acetylhexosaminyltransferase EXTL2 antibody; Alpha 1 antibody; Alpha GalNAcT EXTL2 antibody; Alpha-1 antibody; Alpha-GalNAcT EXTL2 antibody; Exostoses (multiple) like 2 antibody; Exostoses multiple like 2 antibody; Exostosin like 2 antibody; Exostosin like glycosyltransferase 2 antibody; EXT L2 antibody; EXT related protein 2 antibody; EXT-related protein 2 antibody; EXTL 2 antibody; EXTL2 antibody; EXTL2_HUMAN antibody; EXTR 2 antibody; EXTR2 antibody; Glucuronyl galactosyl proteoglycan 4 alpha N acetylglucosaminyltransferase antibody; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody; Multiple exostoses like 2 antibody; Processed exostosin like 2 antibody; Processed exostosin-like 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human EXTL2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
Gene References into Functions
  1. EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for proteoglycans PMID: 23395820
  2. Lysosomal glycosaminoglycan levels in mucopolysaccharidosis are reduced by EXTL2 gene silencing. PMID: 19690583
  3. donor binding appears to undergo two distinct steps, beginning with the N-acetyl group expelling water from the donor- enzyme complex into the bulk solvent followed by positioning of the donor into the binding site for interactions with the enzyme PMID: 15831490
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed exostosin-like 2]: Secreted. Note=A soluble form is found in the serum.
Protein Families
Glycosyltransferase 47 family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 3516

OMIM: 602411

KEGG: hsa:2135

STRING: 9606.ENSP00000359131

UniGene: Hs.357637

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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