EZH1 Antibody

Code CSB-PA852913DA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA852913DA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA852913DA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EZH1 Polyclonal antibody
Uniprot No.
Target Names
EZH1
Alternative Names
Enhancer of zeste homolog 1 (Drosophila) antibody; Enhancer of zeste homolog 1 antibody; ENX-2 antibody; ENX2 antibody; Ezh1 antibody; EZH1_HUMAN antibody; Histone-lysine N-methyltransferase EZH1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Histone-lysine N-methyltransferase EZH1 protein (160-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The EZH1 Antibody (Product code: CSB-PA852913DA01HU) is Non-conjugated. For EZH1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA852913DB01HU EZH1 Antibody, HRP conjugated ELISA
FITC CSB-PA852913DC01HU EZH1 Antibody, FITC conjugated
Biotin CSB-PA852913DD01HU EZH1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Gene References into Functions
  1. identification of EZH1 as a repressor of haematopoietic multipotency in the early mammalian embryo PMID: 29342143
  2. pVHL loss causes the transcriptional activation of hypoxia-inducible factor (HIF) target genes, including many genes that encode histone lysine demethylases. PMID: 28701475
  3. Data show that embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages. PMID: 28939884
  4. Expression of the EZH2 homolog EZH1 is reduced in EZH2-deficient CML LICs, creating a scenario resembling complete loss of PRC2. EZH2 dependence of CML LICs raises prospects for improved therapy of TKI-resistant CML and/or eradication of disease by addition of EZH2 inhibitors PMID: 27630126
  5. a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells PMID: 27500488
  6. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
  7. The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes. PMID: 28346433
  8. These evidences suggest that EZH2 and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas PMID: 27311868
  9. The related enzymatic subunits EZH1 and EZH2 undergo an expression switch during blood cell development. PMID: 25578878
  10. EZH1 maintains repressive chromatin through different mechanisms. PMID: 19026781

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Subcellular Location
Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
Protein Families
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
Database Links

HGNC: 3526

OMIM: 601674

KEGG: hsa:2145

STRING: 9606.ENSP00000404658

UniGene: Hs.194669

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