EZH1

EZH1, also known as the enhancer of zeste homolog 1 or human EZH2-related protein KIAA0999, is an enzyme encoded by the EZH1 gene. It serves as the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is integral to epigenetic regulation. EZH1's primary function is to catalyze the methylation of histone H3 at lysine 27, leading to the formation of H3K27me3, an epigenetic mark that typically represses gene expression. This enzyme plays a crucial role in cellular processes including proliferation, differentiation, development, and tumor formation. Dysregulation of EZH1 is often associated with the genesis and progression of various types of cancer, making it a promising therapeutic target for oncology.