FAM96B Antibody

Code CSB-PA897544ESR1HU
Size US$166
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  • Western blot
    All lanes: FAM96B antibody at 7.23µg/ml
    Lane 1: Mouse gonadal tissue
    Lane 2: MCF-7 whole cell lysate
    Lane 3: Hela whole cell lysate
    Lane 4: K562 whole cell lysate
    Lane 5: A375 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 18 kDa
    Observed band size: 18 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA897544ESR1HU at dilution of 1:100

  • Immunoprecipitating FAM96B in Hela whole cell lysate
    Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA897544ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
    Lane 2: CSB-PA897544ESR1HU (4µg) + Hela whole cell lysate (500µg)
    Lane 3: Hela whole cell lysate (20µg)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FAM96B Polyclonal antibody
Uniprot No.
Target Names
FAM96B
Alternative Names
CGI 128 antibody; FAM96B antibody; Family with sequence similarity 96; member B antibody; HSPC118 antibody; Hypothetical protein LOC51647 antibody; MIP18 antibody; MIP18_HUMAN antibody; Mitotic spindle-associated MMXD complex subunit MIP18 antibody; MSS19-interacting protein of 18 kDa antibody; Protein FAM96B antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Mitotic spindle-associated MMXD complex subunit MIP18 protein (1-163AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC, IP
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
IP 1:200-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.
Gene References into Functions
  1. Data suggest that CIA2B and MMS19 physically interact with C-terminus of viperin/RSAD2; CIAO1 appears to function as primary viperin-interacting protein; CIA2A binds to N-terminus of viperin in CIAO1-, CIA2B-, and MMS19-independent fashion. (CIA2B = metallochaperone CIA2B/FAM96B; MMS19 = transcription factor MMS19; CIAO1 = cytosolic iron-sulfur assembly component 1; CIA2A = metallochaperone CIA2A/Fam96a) PMID: 28615450
  2. CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization. PMID: 23891004
  3. Co-localization experiments by fluorescent confocal microscopy revealed that FAM96B colocalized with prelamin A in HEK-293 cells. PMID: 24041693
  4. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. PMID: 23150669
  5. these findings suggest that FAM96B acts as a regulator of E2-2 through the control of its protein expression. PMID: 21722264

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Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
Protein Families
MIP18 family
Database Links

HGNC: 24261

OMIM: 614778

KEGG: hsa:51647

STRING: 9606.ENSP00000387471

UniGene: Hs.9825

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