FTCD Antibody

Datasheet

Code	CSB-PA009029ESR2HU
Size	US$166
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Image	Western blot All lanes: FTCD antibody at 5.46μg/ml Lane 1: HepG2 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 59, 62, 53, 17 kDa Observed band size: 59 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009029ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA009029ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FTCD Polyclonal antibody

Uniprot No.

O95954

Target Names

FTCD

Alternative Names

Formimidoyltetrahydrofolate cyclodeaminase antibody; Formimidoyltransferase cyclodeaminase antibody; Formiminotetrahydrofolate cyclodeaminase antibody; Formiminotransferase cyclodeaminase antibody; Formiminotransferase-cyclodeaminase antibody; FTCD antibody; FTCD_HUMAN antibody; Glutamate formiminotransferase antibody; Glutamate formyltransferase antibody; LCHC 1 antibody; LCHC1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Formimidoyltransferase-cyclodeaminase protein (412-541AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.

Gene References into Functions

The formiminotransferase-cyclodeaminase allelic spectrum comprised of 12 distinct variants including 5 missense alterations, an in-frame deletion, two frameshift variants and four nonsense variants with the remaining alterations predicted to affect mRNA processing/stability. PMID: 29178637
FTCD is a positive regulator of the hypoxia-HIF signaling pathway and has an important role in cell proliferation, metabolism and migration in HepG2 cells PMID: 24686083
The FTCD promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology PMID: 20209057
Disease-causing mutations have been identified in the FTCD gene in three patients with the putative autosomal recessive disorder glutamate formiminotransferase deficiency. PMID: 12815595

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Involvement in disease

Glutamate formiminotransferase deficiency (FIGLU-URIA)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Note=More abundantly located around the mother centriole.

Protein Families

Cyclodeaminase/cyclohydrolase family; Formiminotransferase family

Database Links

HGNC: 3974

OMIM: 229100

KEGG: hsa:10841

STRING: 9606.ENSP00000291670

UniGene: Hs.415846

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The Overview of Organelles Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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