GANAB Antibody

Code CSB-PA008333
Size US$100
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  • Western Blot analysis of LOVO cells using Glucosidase IIα Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
GANAB
Alternative Names
Alpha glucosidase II alpha subunit antibody; Alpha-glucosidase 2 antibody; G2AN antibody; GANAB antibody; GANAB_HUMAN antibody; Glu II antibody; Glucosidase alpha neutral AB antibody; Glucosidase II alpha antibody; Glucosidase II subunit alpha antibody; GluII antibody; KIAA0088 antibody; Neutral alpha glucosidase AB antibody; Neutral alpha glucosidase AB precursor antibody; Neutral alpha-glucosidase AB antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human Glucosidase IIα.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
Gene References into Functions
  1. Case Report: GANAB mutation leading to autosomal dominant polycystic kidney disease. PMID: 28784653
  2. Mutations in GANAB gene is associated with Autosomal-Dominant Polycystic Kidney and Liver Disease. PMID: 27259053
  3. The high frequency of glucosidase II overexpression, which to the best of our knowledge has not been previously described, indicates its crucial roles in lung tumorigenesis and is thus a valuable biomarker PMID: 24008518
  4. Loss of the tumor suppression function of Hsp60 or GANAB contribute to aggressive cancers. PMID: 21642380
  5. In males being treated for infertility, neutral alpha-glucosidase activity correlated with the percentage of sperm DNA fragmentation. PMID: 19737279
  6. the apparent occurrence of an unusual TG 3' splice site in intron 18 is discussed PMID: 17672918

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Involvement in disease
Polycystic kidney disease 3 (PKD3)
Subcellular Location
Endoplasmic reticulum. Golgi apparatus. Melanosome.
Protein Families
Glycosyl hydrolase 31 family
Tissue Specificity
Detected in placenta. Isoform 1 and isoform 2 are expressed in the kidney and liver.
Database Links

HGNC: 4138

OMIM: 104160

KEGG: hsa:23193

STRING: 9606.ENSP00000340466

UniGene: Hs.595071

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