GCSAM Antibody

1. Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms. PMID: 25203428
2. These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes. PMID: 25381061
3. HGAL and LMO2 may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract. PMID: 22914613
4. the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation. PMID: 23299888
5. HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma. PMID: 22743653
6. Immunostaining for HGAL was more frequently positive than that for BCL6 and CD10 in follicular lymphomas PMID: 21988858
7. Data suggest that both HGAL and LMO2 are directly regulated by the transcription repressor PRDM1--overexpression of PRDM1 down-regulates HGAL and LMO2; PRDM1 directly binds to promoters of both HGAL and LMO2 and represses genetic transcription. PMID: 21722313
8. necessary for germinal center maintenance and confining B-cells to the germinal center microenvironment PMID: 21475040
9. show that HGAL increases the binding of myosin to F-actin and inhibits the ability of myosin to translocate actin by reducing the maximal velocity of myosin head/actin movement PMID: 21447067
10. HGAL is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites PMID: 21502424
11. molecular mechanism underlying the inhibitory effects of germinal center-specific HGAL protein on the motility of GC-derived lymphoma cells PMID: 20844236
12. Our results show that HGAL and LMO2 are sensitive markers for follicular lymphoma diagnosis. PMID: 20697248
13. Study confirms and validates findings of a correlation between HGAL expression and outcome in classical HL. PMID: 19883310
14. gene is induced by IL4 and expression strongly predicts survival in diffuse large B-cell lymphoma PMID: 12509382
15. Results report the cloning of germinal center B-cell expressed transcripts 1 and 2 (GCET1 and 2), and show that both are expressed in follicular lymphoma and diffuse large B-cell lymphoma with germinal center B-cell differentiation PMID: 12819018
16. The restricted expression and germinal center specificity of HGAL protein suggest that it may have an important role in the diagnosis of specific lymphomas PMID: 15677569
17. HGAL is involved in negative regulation of lymphocyte migration, thus constraining lymphocytes to the germinal center PMID: 17823310
18. The correlation of HGAL expression with the germinal center B-cell phenotype demonstrates the role of this marker in the classification of cutaneous large B-cell lymphomas PMID: 18264083
19. results report the cloning of HGAL, a germinal center its expression pattern in normal tissues and hematologic malignancies, its induction by IL4, and the prognostic significance of its expression in predicting survival in diffuse large B-cell lymphoma PMID: 12509382

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HGNC: 20253

OMIM: 607792

KEGG: hsa:257144

STRING: 9606.ENSP00000419485

UniGene: Hs.49614