GPX7 Antibody

Code CSB-PA009872GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GPX7
Alternative Names
CL683 antibody; FLJ14777 antibody; Glutathione peroxidase 7 antibody; GPx-7 antibody; GPX6 antibody; GPX7 antibody; GPX7_HUMAN antibody; GSHPx-7 antibody; NPGPx antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human GPX7
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Gene References into Functions
  1. SNPs most associated with Chemotherapy-induced peripheral neuropathy were in ATP-binding cassette sub-family C member 4 (ABCC4) gene. PMID: 25586538
  2. Loss of glutathione peroxidase 7 promotes TNF-alpha-induced NF-kappaB activation in Barrett's carcinogenesis. PMID: 24692067
  3. GPx7 promotes oxidative protein folding, directly utilizing Ero1alpha-generated hydrogen peroxide in the early secretory compartment. PMID: 23919619
  4. tumour suppressor functions in esophageal adenocarcinomas and silenced by location-specific promoter DNA methylation PMID: 23580780
  5. NPGPx protects against fat accumulation in mice and human via modulating ROS PMID: 23828861
  6. GPx7 is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys mechanism in which GSH and PDI are alternative substrates. PMID: 23454490
  7. NPGPx is essential for releasing excessive ER stress by enhancing GRP78 chaperone activity to maintain physiological homeostasis. PMID: 23123197
  8. GPx7 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase PMID: 21215271
  9. NPGPx plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism PMID: 15294905

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Involvement in disease
Barrett esophagus (BE)
Subcellular Location
Secreted.
Protein Families
Glutathione peroxidase family
Tissue Specificity
Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.
Database Links

HGNC: 4559

OMIM: 614266

KEGG: hsa:2882

STRING: 9606.ENSP00000354677

UniGene: Hs.43728

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