GPX7 Antibody

Code CSB-PA009872LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA009872LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GPX7 Polyclonal antibody
Uniprot No.
Target Names
GPX7
Alternative Names
CL683 antibody; FLJ14777 antibody; Glutathione peroxidase 7 antibody; GPx-7 antibody; GPX6 antibody; GPX7 antibody; GPX7_HUMAN antibody; GSHPx-7 antibody; NPGPx antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Glutathione peroxidase 7 protein (28-187AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GPX7 Antibody (Product code: CSB-PA009872LA01HU) is Non-conjugated. For GPX7 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009872LB01HU GPX7 Antibody, HRP conjugated ELISA
FITC CSB-PA009872LC01HU GPX7 Antibody, FITC conjugated
Biotin CSB-PA009872LD01HU GPX7 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Gene References into Functions
  1. SNPs most associated with Chemotherapy-induced peripheral neuropathy were in ATP-binding cassette sub-family C member 4 (ABCC4) gene. PMID: 25586538
  2. Loss of glutathione peroxidase 7 promotes TNF-alpha-induced NF-kappaB activation in Barrett's carcinogenesis. PMID: 24692067
  3. GPx7 promotes oxidative protein folding, directly utilizing Ero1alpha-generated hydrogen peroxide in the early secretory compartment. PMID: 23919619
  4. tumour suppressor functions in esophageal adenocarcinomas and silenced by location-specific promoter DNA methylation PMID: 23580780
  5. NPGPx protects against fat accumulation in mice and human via modulating ROS PMID: 23828861
  6. GPx7 is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys mechanism in which GSH and PDI are alternative substrates. PMID: 23454490
  7. NPGPx is essential for releasing excessive ER stress by enhancing GRP78 chaperone activity to maintain physiological homeostasis. PMID: 23123197
  8. GPx7 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase PMID: 21215271
  9. NPGPx plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism PMID: 15294905

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Involvement in disease
Barrett esophagus (BE)
Subcellular Location
Secreted.
Protein Families
Glutathione peroxidase family
Tissue Specificity
Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.
Database Links

HGNC: 4559

OMIM: 614266

KEGG: hsa:2882

STRING: 9606.ENSP00000354677

UniGene: Hs.43728

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