GPX8 Antibody

Code CSB-PA848417LA01HU
Size US$166
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  • Immunofluorescent analysis of Hela cells using CSB-PA848417LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA848417LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA848417LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GPX8 Polyclonal antibody
Uniprot No.
Target Names
GPX8
Alternative Names
GPX8; UNQ847/PRO1785; Probable glutathione peroxidase 8; GPx-8; GSHPx-8
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Probable glutathione peroxidase 8 protein (41-209AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GPX8 Antibody (Product code: CSB-PA848417LA01HU) is Non-conjugated. For GPX8 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA848417LB01HU GPX8 Antibody, HRP conjugated ELISA
FITC CSB-PA848417LC01HU GPX8 Antibody, FITC conjugated
Biotin CSB-PA848417LD01HU GPX8 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. Study provides evidence that the conserved N-terminal transmembrane domain of GPX8, in addition to its enzymatic activity, is essential for regulating Ca(2+) dynamics revealing a novel level of integration between redox-related proteins and Ca(2+) signaling/homeostasis. PMID: 28129698
  2. GPX8 is transcriptionally regulated by HIFalpha and modulates growth factor signaling in HeLa cells. PMID: 25557012
  3. Along with the induction of GPX8 in ER-stressed cells, these findings question a ubiquitous role of Ero1alpha as a producer of cytoplasmic ROS under ER stress PMID: 24566470
  4. Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. PMID: 23929719
  5. GPx8 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase PMID: 21215271

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Subcellular Location
Membrane; Single-pass membrane protein.
Protein Families
Glutathione peroxidase family
Database Links

HGNC: 33100

KEGG: hsa:493869

STRING: 9606.ENSP00000423822

UniGene: Hs.289044

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