GRB7 Antibody

Code CSB-PA009890ESR1HU
Size US$166
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  • Western blot
    All lanes: Growth factor receptor-bound protein 7 antibody at 2μg/ml + Rat brain tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 60, 50, 63, 56 kDa
    Observed band size: 60 kDa

  • Immunohistochemistry of paraffin-embedded human esophagus tissue using CSB-PA009890ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GRB7 Polyclonal antibody
Uniprot No.
Target Names
GRB7
Alternative Names
B47 antibody; Epidermal growth factor receptor GRB 7 antibody; Epidermal growth factor receptor GRB-7 antibody; GRB7 adapter protein antibody; GRB7 antibody; GRB7_HUMAN antibody; Growth factor receptor bound protein 7 antibody; Growth factor receptor-bound protein 7 antibody; OTTHUMP00000164349 antibody; OTTHUMP00000164350 antibody; OTTHUMP00000164351 antibody; OTTHUMP00000164352 antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Growth factor receptor-bound protein 7 protein (233-532AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.
Gene References into Functions
  1. MiR-193a-3p not only modulated GRB7 but also ERBB4. PMID: 29290818
  2. Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer PMID: 28780081
  3. data shows that GRB7 expression in invasive breast cancer correlates with markers of a more aggressive phenotype, including HER2 overexpression, a greater degree of HER2 amplification, ER negativity, and p53 positivity PMID: 26945445
  4. The crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain. PMID: 27257138
  5. Grb7 protein Ras-associating domain oligomerization has been reported. PMID: 28295715
  6. Study provided a direct link between the signal adapter protein Grb7, anti-apoptotic protein Hax1 isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1-related apoptosis pathways mediated by Caspase3. PMID: 26869103
  7. Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization. PMID: 26617853
  8. Grb7 was found to be significantly related to the biological classification of breast cancer PMID: 25182704
  9. apo Grb7 SH2 domain crystallized in the trigonal space group P63, whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21 PMID: 24637751
  10. The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2+ve cell types PMID: 24464577
  11. Data suggest that calmodulin controls Grb7-mediated cell migration. PMID: 23743201
  12. Data propose the phosphorylation state of Grb7-SH2 domain tyrosine residues could control Grb7 dimerization, and dimerization may be an important regulatory step in Grb7 binding to RTKs such as erbB2. PMID: 22811067
  13. GRB7 is a context-dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt. PMID: 22584052
  14. propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS PMID: 22673522
  15. A series of Grb7 SH2 domain-binding nonphosphorylated peptides in the yeast two-hybrid system, were identified. PMID: 22253820
  16. GRB7 protein over-expression is an independent adverse prognostic factor in human breast cancer PMID: 20635137
  17. Full-length Grb7 and Hax-1 interact in mammalian cells and Grb7 is tyrosine phosphorylated. PMID: 20665473
  18. X-ray diffraction data were collected from crystals to 2.4A resolution for G7-18NATE in complex with its Grb7 SH2 domain. PMID: 21139214
  19. proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation PMID: 20370637
  20. Data show that Grb7 removal by RNA-interference reduces breast cancer cell viability. PMID: 20126311
  21. Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy. PMID: 20622016
  22. Studies implicate that the overexpressed GRB7 and GRB7v are associated with high-grade tumors and exert distinct tumorigenic functions through regulating different signaling pathways in ovarian cancer cells. PMID: 20388850
  23. High Grb7 is associated with breast cancer. PMID: 19717535
  24. Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7 PMID: 11809769
  25. the PH domain mediated Grb7 binding to phospholipids PMID: 12021278
  26. NMR assignments of backbone 1H, 13C, and 15N resonances of Grb7-SH2 domain in complex with a phosphorylated peptide ligand PMID: 12061724
  27. review of GRB7 binding sites and molecular interactions, and role in progression and invasive potential in cancer, making it a target for therapeutics PMID: 14585167
  28. Incresaed Grb7 expression is associated with disease progression in chronic lymphocytic leukemia PMID: 15470489
  29. Human Grb7 specifically binds CaM in a calcium2+-dependent manner; possible alterations of the Grb7/CaM system in tumor cells could be relevant to high motility seen in many cancer cells PMID: 15806159
  30. Grb7-SH2 domain dimerisation depends on a single point mutation PMID: 15841400
  31. Mutation and elevated expression of GRB7 is associated with the development of testicular germ cell tumors PMID: 16354586
  32. Grb7 expression was statistically significantly different between specimens from patients with or without lymph node metastasis. PMID: 16595785
  33. The Grb7 peptide has potential to be developed as a therapeutic agent alone, or in combination with traditional chemotherapy. PMID: 17426702
  34. Grb7 plays an important role in hepatocellular carcinoma progression and is strongly associated with expression of focal adhesion kinase. PMID: 17634422
  35. The solution structure and the backbone relaxation behavior of the Grb7-SH2/erbB2 peptide complex. PMID: 17705331
  36. GRB-7 over-expression plays pivotal roles in activating signal transduction and promoting tumor growth in breast cancer cells with chromosome 17q11-21 amplification PMID: 17916906
  37. Formation of focal adhesion kinase *Grb7 complexes and Grb7 phosphorylation by FAK in an integrin-dependent manner were essential for cell migration, proliferation and anchorage-independent growth in A431 epidermal carcinoma cells. PMID: 19473962
  38. Results illuminate the membrane-recruitment mechanisms of Grb7, Grb10 and Grb14. PMID: 19648926
  39. Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus. PMID: 15010812

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Subcellular Location
Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Cell projection.
Protein Families
GRB7/10/14 family
Database Links

HGNC: 4567

OMIM: 601522

KEGG: hsa:2886

STRING: 9606.ENSP00000403459

UniGene: Hs.86859

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