GREB1 Antibody

1. GREB1 is a novel progesterone-responsive gene required for endometrial stromal decidualization. PMID: 28911214
2. The aim of this study was to determine if genetic variation within GREB1 was associated with BMD variation. PMID: 28293781
3. Whole exome sequence analysis of two families with renal agenesis identified a single candidate gene, GREB1L. Data implicates GREB1L as a coactivator for RARs. PMID: 28739660
4. Which were rescued by wild-type human GREB1L mRNA. PMID: 29100090
5. A significant association between GREB1L variants and BKA. PMID: 29100091
6. the GREB1 region on chromosome 2p25.1 and the GREB1 gene may play a role in endometriosis risk PMID: 25788566
7. GREB1 is a critical mediator of both the estrogen-stimulated proliferation of breast cancer cells and the androgen-stimulated proliferation of prostate cancer cells PMID: 24998469
8. The expression of Greb1 was up-regulated in mouse tumors treated with E2 and was overexpressed in human ovarian cancers relative to human ovarian surface epithelium, suggesting a role for GREB1 in human ovarian tumor progression. PMID: 24469735
9. RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population. PMID: 23876972
10. GREB1 is one of the central estrogen-specific ER cofactors, where it functions to mediate interactions between the ER and additional proteins. PMID: 23403292
11. GREB1 alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis. PMID: 22884659
12. in ER-positive breast cancer cells, LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1 PMID: 22359603
13. Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis. PMID: 19945309
14. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
15. Characterize a monoclonal antibody that recognizes GREB1 protein in breast cancer cells. PMID: 19842031
16. GREB1 is critically involved in the estrogen induced growth of breast cancer cells. PMID: 15986123
17. GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation. PMID: 16496412
18. Data show that the induction of the gene regulated in breast cancer 1 (GREB1) is mediated by binding of estrogen receptor alpha to three consensus estrogen response elements spread over approximately 20 kb of upstream flanking sequences. PMID: 17463000
19. estrogen-stimulated GREB1 transcription may involve coordinated ER binding to all three distal consensus ERE motifs PMID: 17666587
20. GREB1 is expressed in human skin, and is dose-dependently induced by topical 17-beta-estradiol treatment PMID: 18794456
21. Estrogen receptors are recruited at several proximal and distal estrogen response elements upstream of the GREB1 transcription unit. PMID: 15001666

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HGNC: 24885

OMIM: 611736

KEGG: hsa:9687

STRING: 9606.ENSP00000234142

UniGene: Hs.467733