GRIPAP1 Antibody

Datasheet

Code	CSB-PA009923GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q4V328

Target Names

GRIPAP1

Alternative Names

DKFZp434P0630 antibody; DXImx47e antibody; GRAP1_HUMAN antibody; GRASP 1 antibody; GRASP-1 antibody; GRASP1 antibody; GRIP 1 associated protein 1 antibody; GRIP associated protein 1 antibody; GRIP1 associated protein 1 antibody; GRIP1-associated protein 1 antibody; GRIPAP 1 antibody; GRIPAP1 antibody; KIAA1167 antibody; MGC126593 antibody; MGC126595 antibody; MPMGp800B12492Q3 antibody; Sfc10 antibody; TAMALIN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human GRIPAP1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity.; Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.

Gene References into Functions

We identified a new TFE3 fusion partner, GRIPAP1, in translocation renal cell carcinoma PMID: 28106924
results demonstrate a requirement for normal recycling endosome function in AMPAR-dependent synaptic function and neuronal connectivity in vivo, and suggest a potential role for GRASP1 in the pathophysiology of human cognitive disorders. PMID: 28285821
GRASP-1 was identified as an soluble autoantigen that has numerous coiled-coil domains throughout the protein. PMID: 15897011
Results suggest that GRASP-1 serves as a scaffold protein to facilitate MEKK-1 activation of JNK signaling in neurons. PMID: 17761173

Subcellular Location

Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse.

Database Links

HGNC: 18706

OMIM: 300408

KEGG: hsa:56850

STRING: 9606.ENSP00000365624

UniGene: Hs.109929

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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