HES6 Antibody

1. High HES6 expression is associated with metastasis in colorectal cancer. PMID: 30015909
2. prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported. PMID: 25864518
3. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer. PMID: 25006183
4. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. PMID: 24737870
5. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility. PMID: 22982728
6. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. PMID: 21785461
7. Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells. PMID: 19891787
8. Differentially expressed in metastatic colon carcinoma PMID: 12957362
9. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. PMID: 12972610
10. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation. PMID: 15896295
11. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression PMID: 17300753
12. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. PMID: 17301032
13. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
14. the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways. PMID: 18160400
15. These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed. PMID: 19481584

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HGNC: 18254

OMIM: 610331

KEGG: hsa:55502

STRING: 9606.ENSP00000272937

UniGene: Hs.42949