HSBP1 Antibody

Code CSB-PA00454A0Rb
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA00454A0Rb at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA00454A0Rb at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HSBP1 Polyclonal antibody
Uniprot No.
Target Names
HSBP1
Alternative Names
Heat shock factor binding protein 1 antibody; Heat shock factor-binding protein 1 antibody; HSBP1 antibody; HSBP1_HUMAN antibody; HSF1BP antibody; Nasopharyngeal carcinoma associated antigen 13 antibody; Nasopharyngeal carcinoma-associated antigen 13 antibody; NPC A 13 antibody; NPC-A-13 antibody; NPCA 13 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Heat shock factor-binding protein 1 protein (1-75AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The HSBP1 Antibody (Product code: CSB-PA00454A0Rb) is Non-conjugated. For HSBP1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA00454B0Rb HSBP1 Antibody, HRP conjugated ELISA
FITC CSB-PA00454C0Rb HSBP1 Antibody, FITC conjugated
Biotin CSB-PA00454D0Rb HSBP1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Gene References into Functions
  1. HSPB1 protects cells against proapoptotic agents when expressed at high level, while inhibition of its expression has been found to predispose cells to apoptosis. PMID: 28828227
  2. Results presented here show that acquisition of a positive charge in HSBP1, either by protonation of His124 or its substitution by lysine, reduces the stability of the dimer interface of the alpha-crystallin domain, increases oligomeric size, and modestly increases chaperone activity. PMID: 28332148
  3. HSBP1 is crucial for regulating resistance to radiotherapy of oral squamous epithelial carcinoma cells by inducing stem-like status. PMID: 24816843
  4. HspBP1 inhibited the cytotoxic activity of the Tag7-Hsp70 complex secreted by lymphocytes. HspBP1 PMID: 21247889
  5. This study reports the crystal structure of a degradation-resistant fragment of HSBP1. A continuous, long-helix conformation of HSBP1 assembles into a coiled-coil three-helix bundle and subsequently into an elongated, symmetrical hexamer. PMID: 18767159
  6. HSBP likely mediates its function through its trimerization domain. PMID: 11679589

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Subcellular Location
Nucleus.
Protein Families
HSBP1 family
Database Links

HGNC: 5203

OMIM: 604553

KEGG: hsa:3281

STRING: 9606.ENSP00000392896

UniGene: Hs.250899

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