ING3 Antibody

Code CSB-PA865171LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, Mouse brain tissue
    All lanes: DACH1 antibody at 2.8μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 47, 12 kDa
    Observed band size: 79 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA865171LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA865171LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ING3 Polyclonal antibody
Uniprot No.
Target Names
ING3
Alternative Names
ING3 antibody; HSPC301 antibody; Inhibitor of growth protein 3 antibody; p47ING3 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Inhibitor of growth protein 3 protein (51-223AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ING3 Antibody (Product code: CSB-PA865171LA01HU) is Non-conjugated. For ING3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA865171LB01HU ING3 Antibody, HRP conjugated ELISA
FITC CSB-PA865171LC01HU ING3 Antibody, FITC conjugated
Biotin CSB-PA865171LD01HU ING3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:2000-1:10000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Gene References into Functions
  1. results reveal the molecular mechanism of H3K4me3 selection by the ING3PHD and suggest that this interaction is important for mediating ING3 tumor suppressive activities. PMID: 27281824
  2. High ING3 expression is associated with prostate cancer. PMID: 26803516
  3. ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer. PMID: 25819753
  4. Downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. PMID: 24927342
  5. that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target. PMID: 22550337
  6. Data show that ING3 is degraded by the ubiquitin-proteasome pathway through the SCF(Skp2) complex. PMID: 19935701
  7. we have isolated a novel ING family gene, p47ING3, which modulates p53-mediated transcription, cell cycle control, and apoptosis. The p47ING3 gene is located at chromosome 7q31.3 and consists of 12 exons that encode 418 amino acids PMID: 12545155
  8. ING3 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target. PMID: 17634537
  9. ING3 would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer. PMID: 18081876
  10. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. PMID: 12080476

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Involvement in disease
Squamous cell carcinoma of the head and neck (HNSCC)
Subcellular Location
Nucleus.
Protein Families
ING family
Tissue Specificity
Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
Database Links

HGNC: 14587

OMIM: 275355

KEGG: hsa:54556

STRING: 9606.ENSP00000320566

UniGene: Hs.489811

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