IPO13 Antibody

Datasheet

Code	CSB-PA011776LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HEK293 whole cell lysate, Hela whole cell lysate, A549 whole cell lysate All lanes: IPO13 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 109 kDa Observed band size: 109 kDa Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA011776LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA011776LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) IPO13 Polyclonal antibody

Uniprot No.

O94829

Target Names

IPO13

Alternative Names

Imp 13 antibody; Imp13 antibody; Importin-13 antibody; Importin13 antibody; IPO 13 antibody; Ipo13 antibody; IPO13_HUMAN antibody; Kap 13 antibody; Kap13 antibody; Karyopherin 13 antibody; Karyopherin-13 antibody; Karyopherin13 antibody; KIAA0274 antibody; Late gestation lung 2 antibody; Late gestation lung 2 protein antibody; Lgl2 antibody; Ran binding protein 13 antibody; Ran-binding protein 13 antibody; RanBP 13 antibody; RanBP13 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Importin-13 protein (501-700AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The IPO13 Antibody (Product code: CSB-PA011776LA01HU) is Non-conjugated. For IPO13 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA011776LB01HU	IPO13 Antibody, HRP conjugated	ELISA
FITC	CSB-PA011776LC01HU	IPO13 Antibody, FITC conjugated
Biotin	CSB-PA011776LD01HU	IPO13 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Gene References into Functions

IPO13 influenced intracellular distribution of CTCF. PMID: 23620300
IPO13 may contribute to the pathogenesis of pterygium via modulation of K17 and c-Jun. PMID: 23559854
Imp13 is able to bind and export eIF1A in vivo and that its function is essential. PMID: 23435562
These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma. PMID: 22648251
Data show that expression of IPO13, c-kit, telomerase, caspase3, and CD146 are decreased in endometrial polyps; however, the expression of bcl-2 was increased in polyps compared to the normal endometrial tissue. PMID: 21804459
IPO13 is uniquely expressed by human limbal basal epithelial cells, and plays an important role in maintaining the phenotype, high proliferative potential, and less differentiation of corneal epithelial progenitor cells. PMID: 19593795
Imp13 functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation. PMID: 17828378
Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers PMID: 19218565
IPO13 variation may improve nuclear bioavailability of endogenous glucocorticoids PMID: 19619331

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Importin beta family

Tissue Specificity

Expressed in fetal brain, heart, intestine and kidney.

Database Links

HGNC: 16853

OMIM: 610411

KEGG: hsa:9670

STRING: 9606.ENSP00000361418

UniGene: Hs.158497

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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