KLF7 Antibody

Code CSB-PA012397GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
KLF7
Alternative Names
KLF7 antibody; KLF7_HUMAN antibody; Krueppel like factor 7 antibody; Krueppel-like factor 7 antibody; Kruppel like factor 7 antibody; Ubiquitous krueppel like factor antibody; Ubiquitous krueppel-like factor antibody; UKLF antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human KLF7
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional factor. Plays a critical role in neuronal morphogenesis and survival of sensory neurons. Represses the corneal epithelium differentiation. Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin.
Gene References into Functions
  1. Kruppel family member KLF7 promotes the corneal progenitor cell state; on many genes, KLF7 antagonized the corneal differentiation-promoting KLF4. PMID: 28916725
  2. KLF7 has an important role in gastric cancer (GC) progression, as it inhibits GC cell migration and may serve as a prognostic marker PMID: 28977783
  3. Higher expression of TLR4 and KLF7 may play a vital role in the process of inflammation induced by obesity in visceral adipose tissue PMID: 27714571
  4. a dominant mutation in FBXO38 causes adult-onset, progressive spinal muscular atrophy with calf predominance PMID: 24207122
  5. KLF7 was upregulated by morphine at both the transcriptional and the translational levels, promoting cell growth up to day 4 PMID: 14644156
  6. The gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes. PMID: 15937668
  7. KLF7 may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues. PMID: 16339272
  8. We identified a novel association between the minor A-allele of KLF7 and protection against obesity in the Danish population PMID: 19147600

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Subcellular Location
Nucleus.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 6350

OMIM: 604865

KEGG: hsa:8609

STRING: 9606.ENSP00000309570

UniGene: Hs.471221

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