LACTB Antibody

Code CSB-PA012716GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
LACTB
Alternative Names
LACTB antibody; MRPL56 antibody; UNQ843/PRO1781Serine beta-lactamase-like protein LACTB antibody; mitochondrial antibody; EC 3.4.-.- antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human LACTB
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism.
Gene References into Functions
  1. observations uncover a novel mitochondrial tumour suppressor, LACTB--and demonstrate a connection between mitochondrial lipid metabolism and the differentiation program of breast cancer cells, thereby revealing a previously undescribed mechanism of tumour suppression PMID: 28329758
  2. MiR-125b-5p attenuates the secretion of MCP-1 by directly targeting inhibiting LACTB in LPS-stimulated THP-1 macrophages. PMID: 26603571
  3. Differential expression of a novel gene, G24, in response to hsp27 and cell differentiation in human keratinocytes.(G24 PROTEIN) PMID: 12164938
Subcellular Location
Mitochondrion.
Protein Families
Peptidase S12 family
Tissue Specificity
Expressed predominantly in skeletal muscle.
Database Links

HGNC: 16468

OMIM: 608440

KEGG: hsa:114294

STRING: 9606.ENSP00000261893

UniGene: Hs.410388

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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