LIN7A Antibody

Datasheet

Code	CSB-PA012963LA01HU
Size	US$166
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Image	Western blot All lanes: LIN7A antibody at 6µg/ml Lane 1: Human placenta tissue Lane 2: Mouse kidney tissue Lane 3: Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LIN7A Polyclonal antibody

Uniprot No.

O14910

Target Names

LIN7A

Alternative Names

hLin-7 antibody; Lin 7 homolog A (C. elegans) antibody; LIN 7A antibody; Lin-7A antibody; LIN7 antibody; LIN7A antibody; LIN7A_HUMAN antibody; MALS-1 antibody; Mammalian LIN 7 1 antibody; Mammalian lin-seven protein 1 antibody; Protein lin-7 homolog A antibody; Tax interaction protein 33 antibody; TIP-33 antibody; Veli-1 antibody; VELI1 antibody; Vertebrate lin-7 homolog 1 antibody; Vertebrate LIN7 homolog 1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Protein lin-7 homolog A protein (1-233AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LIN7A Antibody (Product code: CSB-PA012963LA01HU) is Non-conjugated. For LIN7A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA012963LB01HU	LIN7A Antibody, HRP conjugated	ELISA
FITC	CSB-PA012963LC01HU	LIN7A Antibody, FITC conjugated
Biotin	CSB-PA012963LD01HU	LIN7A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Gene References into Functions

Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 to regulate mitochondrial morphology. PMID: 27320196
This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis. PMID: 26887652
LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome. PMID: 24658322
LIN7A is a PDZ protein that interacts with human papillomavirus-16 E6 and forms a tripartite complex with MPP7 and DLG1, regulating the stability and localization of DLG1 to cell junctions. PMID: 17237226
Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD. PMID: 18286632

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Subcellular Location

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction.

Protein Families

Lin-7 family

Tissue Specificity

Expressed in brain, testis, kidney, placenta and liver.

Database Links

HGNC: 17787

OMIM: 603380

KEGG: hsa:8825

STRING: 9606.ENSP00000447488

UniGene: Hs.144333

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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