LPIN2 Antibody

1. Structural variants unique to the malignant cell line inactivated: LPIN2, a phosphatidic acid phosphatase and a co-factor of PGC1a that is important for lipid metabolism and for suppressing autoinflammation. PMID: 23792589
2. We describe two brothers with Majeed syndrome, homozygous novel 2-base pair deletion in LPIN2 (c.1312_1313delCT; p.Leu438fs+16X) PMID: 23087183
3. LPIN1-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 genes were associated with muscle manifestations. PMID: 22481384
4. role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages PMID: 22334674
5. Data revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3. PMID: 20735359
6. LPIN2 gene was excluded as a candidate for myopia 2 (MYP2), but the SNPs detected in this study will aid in future mapping and association studies involving this gene. PMID: 15862761
7. We conclude that homozygous mutations in LPIN2 result in Majeed syndrome. Understanding the aberrant immune response in this condition will shed light on the aetiology of other inflammatory disorders of multifactorial aetiology PMID: 15994876
8. A single nucleotide polymorphism of the LPIN2 gene is associated with type 2 diabetes and fat distribution. PMID: 17804763
9. distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation PMID: 18694939
10. lipin 2 plays an important role as a hepatic PAP-1 enzyme. PMID: 19136718
11. A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. PMID: 19717560

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HGNC: 14450

OMIM: 605519

KEGG: hsa:9663

STRING: 9606.ENSP00000261596

UniGene: Hs.132342