LSP1 Antibody

1. LSP1 rs3817198 T > C polymorphism is associated with increased risk of breast cancer, especially in Caucasian and Asian populations [meta-analysis] PMID: 27590509
2. These results show that LSP1 is critical regulator of actomyosin contractility in primary macrophages. PMID: 29410425
3. Underexpression of LSP1 is associated with Breast Cancer Recurrence. PMID: 27165221
4. LSP1 rs569550 and rs592373 polymorphisms are both risk factors for breast cancer. PMID: 26191300
5. the importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported. PMID: 26554018
6. The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio: 1.10) This association was strongest for women with adenocarcinoma (P = 1.2x10(-4)). PMID: 24681604
7. Data indicate that slit2N alters the localization and binding of Robo1 to WASp and LSP1 in HIV-1-gp120-treated immature dendritic cells (iDCs). PMID: 23119100
8. Single nucleotide polymorphism in LSP1 is associated with breast cancer. PMID: 22454379
9. The LSP1 rs3817198T>C polymorphism is a low-penetrant risk factor for developing breast cancer but may not be in Africans. PMID: 21127985
10. Low-risk variants of LSP1 is associated with familial breast cancer. PMID: 19856316
11. The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. PMID: 19656774
12. LSP1 interacts with F-actin and the cytoskeleton through residues downstream of amino acid residue 230. The cytoskeleton binding site of mouse LSP1 maps to the 300-330 interval. PMID: 12972289
13. Leukocyte-specific protein 1 is a cytoskeletal targeting protein for the ERK/MAP kinase pathway PMID: 15090600
14. LSP1 protein facilitates virus transport into the proteasome after its interaction with DC-SIGN through its interaction with cytoskeletal proteins. PMID: 17296787
15. MK2-regulated LSP1 phosphorylation is involved in stabilization of F-actin polarization during neutrophil chemotaxis. PMID: 17481585
16. DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1 PMID: 19718030

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HGNC: 6707

OMIM: 153432

KEGG: hsa:4046

STRING: 9606.ENSP00000308383

UniGene: Hs.56729