MAST2 Antibody

Code CSB-PA003196
Size US$100
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  • Western Blot analysis of 293 cells using MAST205 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
MAST2
Alternative Names
EC 2.7.11.1 3 antibody; FLJ39200 antibody; KIAA0807 antibody; MAST 2 antibody; MAST 205 antibody; Mast2 antibody; MAST2_HUMAN antibody; Microtubule associated serine/threonine kinase 2 antibody; Microtubule associated testis specific serine/threonine protein kinase antibody; Microtubule-associated serine/threonine-protein kinase 2 antibody; MTSSK antibody; OTTHUMP00000009697 2 antibody; OTTHUMP00000046616 antibody; RP4 533D7.1 antibody; RP4-533D7.1 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human MAST205.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.
Gene References into Functions
  1. we observed 3 case-specific duplications of the autosomal gene MAST2, and in a replication phase we found another 11 duplications PMID: 26203179
  2. Viral and PTEN peptide interactions to MAST2-PDZ occur via a unique kinetic step which involves both canonical C-terminal PBM binding and N-terminal anchoring. PMID: 25942057
  3. MAST2 gene rearrangements occur in invasive breast carcinoma. PMID: 24140425
  4. MAST205 plays an important role in regulating CFTR expression and function PMID: 23504457
  5. The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells. PMID: 22609064
  6. Recruitment of a MAST2 CpG island was most likely beneficial to the hybrid retrotransposons because it could significantly increase retrotransposition frequency. PMID: 19961423
  7. Studies report the identification of a new subfamily of SVA, which apparently formed after an alternative splicing event where the first exon of the MAST2 gene spliced into an intronic SVA and subsequently retrotransposed. PMID: 19635844

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Subcellular Location
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the sub-membranous area on interaction with CDHR2.
Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Tissue Specificity
Abundant in the testis.
Database Links

HGNC: 19035

OMIM: 612257

KEGG: hsa:23139

STRING: 9606.ENSP00000354671

UniGene: Hs.319481

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