MCM8 Antibody

1. Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype. PMID: 28863940
2. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. PMID: 28487407
3. study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development. PMID: 28481876
4. Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes. PMID: 27802094
5. Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair. PMID: 27573988
6. Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia. PMID: 26823731
7. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These PMID: 25873734
8. An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability. PMID: 25437880
9. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment. PMID: 23401855
10. Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause. PMID: 22696150
11. Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan. PMID: 22131368
12. The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13. PMID: 12771218
13. MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly. PMID: 15684404
14. We find that MCM8, like MCM7, colocalizes on a specific DNA segment of the c-MYC replication initiation zone (c-MYC replicator) of DNA replications together with Cdc6 and cdk2, but differs with MCM7 in spatial relation to RPA70 during S phase. PMID: 18072282

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HGNC: 16147

OMIM: 608187

KEGG: hsa:84515

STRING: 9606.ENSP00000368174

UniGene: Hs.597484