MEP1B Antibody

1. Results provide evidence that meprin beta is involved in collagen deposition in vivo in the lung of bleomycin treated mice and it localized in region with immature collagen. This suggests that meprin beta can favor the progression of the fibrotic process enhancing collagen processing and deposition. PMID: 28059112
2. This secreted cysteine protease potently converts membrane-bound meprin beta into its active form, impairing meprin beta shedding and its function as a mucus-detaching protease PMID: 29166602
3. For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations. PMID: 28365001
4. TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes PMID: 27180358
5. n conclusion, we show that the concept of cleavable linkers specific for meprin beta is feasible, as the peptides are rapidly cleaved by the enzyme while retaining their biological properties PMID: 25855967
6. Meprin Beta was found to be activated at the cell surface by matriptase-2. PMID: 26251449
7. promotes inflammation in macrophages via ADAM-10 dependent pathway PMID: 24239627
8. Overexpression of MEP1B is associated with pancreatic neuroendocrine tumors. PMID: 24114056
9. Suggest role for in meprin-beta-Fra2 axis in mediating vascular remodelling in pulmonary hypertension. PMID: 24258247
10. of the 151 new extracellular substrates identified, it was notable that ADAM10 the constitutive alpha-secretase-is activated by meprin beta through cleavage of the propeptide PMID: 22940918
11. metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species PMID: 22879596
12. Processing of APP by meprin beta was subsequently validated using in vitro and in vivo approaches. N-terminal APP fragments of about 11 and 20 kDa were found in human and mouse brain lysates but not in meprin beta(-/-) mouse brain lysates PMID: 21646356
13. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains. PMID: 20953144
14. data indicate that, at least under pathological conditions, meprinbeta might attack specific functional sites in tenascin-C that are important for its oligomerization and anti-adhesive activity PMID: 19748582
15. results show that the O-linked carbohydrate side chains in hmeprinbeta are clustered around a 13 amino acid sequence that contains the main cleavage site for proteolytic processing of the subunit PMID: 12387727
16. two different metalloprotease activities are responsible for the constitutive and the PMA-stimulated hmeprinbeta shedding PMID: 12941954

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HGNC: 7020

OMIM: 600389

KEGG: hsa:4225

STRING: 9606.ENSP00000269202

UniGene: Hs.194777