MOV10L1 Antibody

Code CSB-PA003266
Size US$100
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  • Western Blot analysis of RAW264.7 cells using MOV10L1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
MOV10L1
Alternative Names
Cardiac helicase activated by MEF2 protein antibody; Cardiac specific RNA helicase antibody; CHAMP antibody; Csm antibody; M10L1_HUMAN antibody; Moloney leukemia virus 10 like protein 1 antibody; Moloney leukemia virus 10-like protein 1 antibody; MOV10 like 1 antibody; MOV10 like protein 1 antibody; MOV10-like protein 1 antibody; MOV10L1 antibody; Mov10l1; Moloney leukemia virus 10 like 1; homolog (mouse) antibody; Putative helicase Mov10l1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human MOV10L1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.
Gene References into Functions
  1. Our results suggest that MOV10L1 gene polymorphisms in the studied infertile males with complete maturation arrest are linked to infertility. PMID: 24817005
Subcellular Location
Cytoplasm.
Protein Families
DNA2/NAM7 helicase family, SDE3 subfamily
Tissue Specificity
[Isoform 1]: Specifically expressed in testis.
Database Links

HGNC: 7201

OMIM: 605794

KEGG: hsa:54456

STRING: 9606.ENSP00000262794

UniGene: Hs.62880

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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