MTMR4 Antibody

Datasheet

Code	CSB-PA798700
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA798700(MTMR4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA798700(MTMR4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

Q9NYA4

Target Names

MTMR4

Alternative Names

FYVE domain containing dual specificity protein phosphatase 2 antibody; FYVE domain-containing dual specificity protein phosphatase 2 antibody; FYVE domain-containing dual specificity protein phosphatase FYVE DSP2 antibody; FYVE-DSP2 antibody; Mtmr4 antibody; MTMR4_HUMAN antibody; Myotubularin related protein 4 antibody; Myotubularin-related protein 4 antibody; ZFYVE11 antibody; zinc finger FYVE domain containing 11 antibody; Zinc finger FYVE domain containing protein 11 antibody; Zinc finger FYVE domain-containing protein 11 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human MTMR4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

Gene References into Functions

Here the authors demonstrate that green fluorescent protein-tagged MTMR4 is recruited to the Salmonella-containing vacuole and infection of cells depleted of endogenous MTMR4 results in a decrease in viable intracellular Salmonella. PMID: 27625994
the PH-GRAM domain of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method PMID: 25195910
MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp signaling PMID: 23150675
MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking. PMID: 20736309
MTMR4 belongs to the myotubularin family of phosphoinositides phosphatases PMID: 9736772
MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes PMID: 20061380
Data found that hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. PMID: 19125695

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Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.

Protein Families

Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily

Tissue Specificity

Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.

Database Links

HGNC: 7452

OMIM: 603559

KEGG: hsa:9110

STRING: 9606.ENSP00000325285

UniGene: Hs.514373

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Autophagy Phosphatidylinositol signaling system

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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