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Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Gene References into Functions
Here the authors demonstrate that green fluorescent protein-tagged MTMR4 is recruited to the Salmonella-containing vacuole and infection of cells depleted of endogenous MTMR4 results in a decrease in viable intracellular Salmonella. PMID: 27625994
the PH-GRAM domain of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method PMID: 25195910
MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp signaling PMID: 23150675
MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking. PMID: 20736309
MTMR4 belongs to the myotubularin family of phosphoinositides phosphatases PMID: 9736772
MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes PMID: 20061380
Data found that hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. PMID: 19125695
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Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Tissue Specificity
Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.