MYLK2 Antibody

Datasheet

Code	CSB-PA189164
Size	US$166
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Image	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: CSB-PA189164(MYLK2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
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Product Details
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Target Background

Product Details

Uniprot No.

Q9H1R3

Target Names

MYLK2

Alternative Names

KMLC antibody; MLCK antibody; MLCK, skeletal/cardiac antibody; MLCK2 antibody; MYLK 2 antibody; MYLK2 antibody; MYLK2_HUMAN antibody; Myosin light chain kinase 2 antibody; Myosin light chain kinase 2 skeletal muscle antibody; Myosin light chain kinase 2 skeletal/cardiac muscle antibody; MYOSIN LIGHT POLYPEPTIDE KINASE antibody; Myosin light polypeptide kinase, skeletal/cardiac antibody; Skeletal muscle myosin light chain kinase antibody; Skeletal myosin light chain kinase antibody; skeletal/cardiac muscle antibody; skMLCK antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human MYLK2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.

Gene References into Functions

the P2X1-ERK2-Myosin Light Chain Kinase axis contributes to collagen-induced platelet activation by enhancing platelet degranulation PMID: 14500714
These data suggest that the kinase domain of MYLK2 is rarely mutated in common human carcinomas and that it does not play a dominant role in cancer pathogenesis. PMID: 16448786
MYLK gene is a risk factor for the development of acute lung injuries. PMID: 18828194
Data show that that the prototypical CaM target sequence skMLCK, a fragment from skeletal muscle myosin light chain kinase, binds to CaM in a highly cooperative way, while only a lower degree of interdomain binding cooperativity emerges for CaMKK. PMID: 19667195

Involvement in disease

Cardiomyopathy, familial hypertrophic (CMH)

Subcellular Location

Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.

Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family

Tissue Specificity

Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.

Database Links

HGNC: 16243

OMIM: 192600

KEGG: hsa:85366

STRING: 9606.ENSP00000365152

UniGene: Hs.86092

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Myosin Regulatory Light Chains (MYL12A and MYL12B): the New Functional Ligands for CD69, Potential Targets for Cardiac Disease or Tumors Research? Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway Focal adhesion Regulation of actin cytoskeleton Vascular smooth muscle contraction Apelin signaling pathway cGMP-PKG signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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