NAB2 Antibody

1. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours. PMID: 28072477
2. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor PMID: 26927892
3. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics. PMID: 24702701
4. Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges. PMID: 27271270
5. NAB2-STAT6 fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain. PMID: 26746203
6. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type. PMID: 26686340
7. Case Report: NAB2-STAT6 fusion in glioblastoma. PMID: 26817999
8. We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors PMID: 26226844
9. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts. PMID: 26883114
10. It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites. PMID: 25893823
11. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features. PMID: 25554652
12. also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17 PMID: 26136329
13. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201). PMID: 25582503
14. reverse transcriptase PCR analysis identified a nerve growth factor inducible-A binding protein 2-STAT6 gene fusion. Our case supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of soft-tissue SFT with loss of CD34 positivity PMID: 25667482
15. Tumors with the most common fusion variant, NAB2ex4-STAT6ex2/3, corresponded to classic pleuropulmonary solitary fibrous tumors with diffuse fibrosis and mostly benign behavior and occurred in older patients PMID: 24513261
16. 44 SFTs were studied to identify pathogenetically important genetic rearrangements. RT-PCR analysis identified a NAB2/STAT6 fusion in 37/41 cases. PMID: 23761323
17. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion PMID: 23575898
18. NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells. PMID: 23416169
19. A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 is the defining driver mutation of solitary fibrous tumor. PMID: 23313952
20. A NAB2-STAT6 fusion is a distinct molecular feature of solitary fibrous tumors. PMID: 23313954
21. p130Cas signaling induces the expression of EGR1 and NAB2 PMID: 22431919
22. Results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. PMID: 20506119
23. Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses PMID: 19888474
24. mutations in the human NAB2 gene are most likely not involved in the pathogenesis of peripheral neuropathies. PMID: 12030330
25. inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. PMID: 12427750
26. Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter in a negative feedback loop PMID: 16260776

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HGNC: 7627

OMIM: 602381

KEGG: hsa:4665

STRING: 9606.ENSP00000300131

UniGene: Hs.159223