NACC1 Antibody

1. knockdown of HOXA9 abrogated NAC1induced drug resistance. PMID: 28713930
2. NAC1 forms a protein complex to function as a transcriptional regulator in cancer cells PMID: 27424155
3. a mutation in NACC1 causes microcephaly, profound developmental delays and/or intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements PMID: 28132692
4. miR-339-5p inhibits migration and invasion in ovarian cancer by targeting NACC1 and BCL6. miR-339-5p may be a biomarker of metastasis in ovarian cancer; NACC1 had a predictive value for ovarian cancer progression PMID: 26553360
5. NAC1 has potential as a marker for distinguishing OED from CIS/OSCC PMID: 26172271
6. NACC1 can be modified by SUMO paralogues, and cooperates with promyelocytic leukemia protein. PMID: 25891951
7. strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported PMID: 25484205
8. low expression of NAC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma. PMID: 23252869
9. The identification of an NAC1 NLS thus clarifies the mechanism through which NAC1 translocates to the nucleus to regulate the transcription of genes involved in oncogenicity and pluripotency. PMID: 22665369
10. Uterine sarcomas with NAC1 overexpression are clinically the most aggressive, chemoresistant, and radioresistant tumors. PMID: 22993327
11. Results not only reveal a previously unrecognized function of NAC1, the molecular pathway involved and its impact on pathogenesis of tumor initiation and development, but also identify a novel senescence regulator PMID: 22665267
12. NAC1 expression was significantly correlated with FASN expression in both OCCC samples and OCCC cell lines. PMID: 22653145
13. NAC1 overexpression is critical to the growth and survival of cervical carcinomas irrespective of histologic type. PMID: 21889186
14. NAC1 is identified as a novel regulator of autophagy PMID: 21743489
15. These data suggest that the acetylation status of CTTN modulated by the NACC1-HDAC6 deacetylation system induces acceleration of melanoma cell migration activity via an actin-dependent cellular process PMID: 21562571
16. Our data suggest that amplification at the ch19p13.2 NACC1 locus, leading to NAC1 overexpression, is one of the molecular genetic alterations associated with early tumor recurrence in ovarian cancer. PMID: 21240255
17. These results indicate that a cell cycle-dependent regulatory mechanism controls NAC1 body formation in the nucleus and suggest that NAC1 body dynamics are associated with mitosis or cytokinesis. PMID: 21301057
18. NAC1 is a potential stem cell pluripotency factor expression in normal endometrium, endometrial hyperplasia and endometrial carcinoma PMID: 20372782
19. NAC1 over-expression is critical to the growth and survival of ovarian cancers. Furthermore, they suggest that NAC1 silencing RNA-induced phenotypes depend on the expression status of the targeted cell line. PMID: 20869761
20. NAC-1 is a tumor recurrence-associated gene with oncogenic potential; interactions between BTB/POZ domains of NAC-1 proteins are critical to form the discrete NAC-1 nuclear bodies and essential for tumor cell proliferation and survival. PMID: 17130457
21. NAC-1 expression is higher in ovarian carcinoma cells in effusions compared with their solid tumor counterparts. PMID: 17391728
22. NAC-1 may play an important role in cervical carcinomas. PMID: 18347169
23. NAC-1 regulates Taxol resistance in ovarian cancer PMID: 18483383
24. Therefore, we conclude that NAC1 functions as a corepressor for POZ/BTB proteins expressed in the mature CNS. PMID: 19121354
25. NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer by inactivating Gadd45v pathway. PMID: 19305429
26. C-terminal alpha-helix of the Nac1 POZ domain is shorter than that observed in most other POZ-domain transcription factors PMID: 19407373

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HGNC: 20967

OMIM: 610672

KEGG: hsa:112939

STRING: 9606.ENSP00000292431

UniGene: Hs.531614