NAGK Antibody

Code CSB-PA015415GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
NAGK
Alternative Names
EC 2.7.1.59 antibody; GlcNAc kinase antibody; GNK antibody; HSA242910 antibody; N acetylglucosamine kinase antibody; N-acetyl-D-glucosamine kinase antibody; N-acetylglucosamine kinase antibody; nagK antibody; NAGK_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NAGK
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.
Gene References into Functions
  1. Data shows associations between NAGK, speckle, paraspeckle and general transcription factor suggesting its regulatory roles in gene expression. PMID: 25921606
  2. Participants with homozygous mutations in the N-acetylmannosamine kinase (GNK) domain have an earlier disease onset than heterozygous participants with mutations in the uridine diphosphate-N-acetylglucosamine 2-epimerase (GNE) and GNK domains. PMID: 22507750
  3. The cell-free system was validated for MNK activity, and it revealed that mutations in one enzymatic domain (in MNK, A631V, M712T) affected not only that domain's enzyme activity, but also the activity of the other domain. PMID: 15987957
  4. Phosphorylation of Tyr205 may modulate GlcNAc kinase activity and/or specificity. PMID: 17010375
Protein Families
Eukaryotic-type N-acetylglucosamine kinase family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 17174

OMIM: 606828

KEGG: hsa:55577

STRING: 9606.ENSP00000389087

UniGene: Hs.7036

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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