NELFCD Antibody

Datasheet

Code	CSB-PA023471GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q8IXH7

Target Names

NELFCD

Alternative Names

HSPC130 antibody; Negative elongation factor C/D antibody; NELF C antibody; NELF D antibody; NELF-C/D antibody; NELFC antibody; NELFD antibody; NELFD_HUMAN antibody; TH1 antibody; TH1-like protein antibody; TH1L antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human TH1L

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.

Gene References into Functions

Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. PMID: 22238675
TH1 might play an important role in regulation of proliferation and invasion in human breast cancer. PMID: 20735431
These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes. PMID: 20069563
diverse transcriptional consequence of NELF-mediated RNAPII pausing in the human genome PMID: 20028984
In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. PMID: 11952167
Trihydrophobin 1 negatively regulates A-Raf kinase PMID: 14684750
A study was done of ubiquitin-dependent proeolysis of TH1L protein by E6-AP. PMID: 17131388
Maternal serum Th1 cytokines concentrations increase in preterm and term delivery. PMID: 17621989
TH1 interacts with PAK1 and specifically restricts the activation of MAPK modules through the upstream region of the MAPK pathway, thereby influencing cell migration. PMID: 19136554

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Subcellular Location

Nucleus.

Protein Families

NELF-D family

Tissue Specificity

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.

Database Links

HGNC: 15934

OMIM: 605297

KEGG: hsa:51497

STRING: 9606.ENSP00000342300

UniGene: Hs.517148

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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