NFE2L3 Antibody

Datasheet

Code	CSB-PA896721LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, U87 whole cell lysate, 293T whole cell lysate, Jurkat whole cell lysate All lanes: NFE2L3 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 77 kDa Observed band size: 77 kDa IHC image of CSB-PA896721LA01HU diluted at 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NFE2L3 Polyclonal antibody

Uniprot No.

Q9Y4A8

Target Names

NFE2L3

Alternative Names

NFE2L3 antibody; NRF3 antibody; Nuclear factor erythroid 2-related factor 3 antibody; NF-E2-related factor 3 antibody; NFE2-related factor 3 antibody; Nuclear factor antibody; erythroid derived 2 antibody; like 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nuclear factor erythroid 2-related factor 3 protein (132-260AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NFE2L3 Antibody (Product code: CSB-PA896721LA01HU) is Non-conjugated. For NFE2L3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA896721LB01HU	NFE2L3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896721LC01HU	NFE2L3 Antibody, FITC conjugated
Biotin	CSB-PA896721LD01HU	NFE2L3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Activates erythroid-specific, globin gene expression.

Gene References into Functions

SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM. PMID: 28554271
findings reveal FBW7 and GSK3 as novel regulators of the NFE2L3 transcription factor and a potential mechanism by which FBW7 might regulate detoxification and the cellular response to stress PMID: 26306035
17beta-Estradiol treatment significantly increased but VC or Res decreased Nrf3 mRNA and protein expression levels. PMID: 25130429
Nrf3 is a negative regulator of ARE-mediated gene expression of NQO1 PMID: 15385560
NRF3 is highly expressed in primary placental cytotrophoblasts PMID: 15388789
Nrf3 is an N-glycosylated protein associated with the endoplasmic reticulum PMID: 17976382

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Subcellular Location

Nucleus.

Protein Families

BZIP family, CNC subfamily

Tissue Specificity

Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.

Database Links

HGNC: 7783

OMIM: 604135

KEGG: hsa:9603

STRING: 9606.ENSP00000056233

UniGene: Hs.404741

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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