NFYC Antibody

1. NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival. PMID: 27495011
2. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
4. the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin and the formation of fat droplets were impaired. PMID: 23657974
5. NFY-C expression was elevated in colorectal adenocarcinomas; moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease PMID: 22104449
6. Sp1, NF-Y and FOXO transcription factors are involved in the regulation of LKB1 transcription. PMID: 22412893
7. NF-YC functions as a new corepressor of agonist-bound mineralocorticoid receptor via alteration of aldosterone-induced MR conformation PMID: 20054001
8. role in repressing Smad2 and Smad3 transactivating activity PMID: 12023901
9. C/EBPbeta contributes to the induction of hepatocyte replication in response to HGF in rodents, which is likely due to post-translational modifications. PMID: 15922473
10. Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple neoplasms. PMID: 19559782
11. NF-YC complexity is generated by dual promoters and alternative splicing PMID: 19690168

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HGNC: 7806

OMIM: 605344

KEGG: hsa:4802

STRING: 9606.ENSP00000396620

UniGene: Hs.713051