NKX2-6 Antibody

Datasheet

Code	CSB-PA877108
Size	US$297
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Image	Western blot analysis of extracts from HeLa cells and COLO cells, using NKX26 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NKX2-6 Polyclonal antibody

Uniprot No.

A6NCS4

Target Names

NKX2-6

Alternative Names

NKX2-6 antibody; NKX2F antibody; Homeobox protein Nkx-2.6 antibody; Homeobox protein NK-2 homolog F antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human NKX26.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.

Gene References into Functions

This study firstly links NKX2.6 loss-of-function mutation with increased susceptibility to isolated VSD. PMID: 25380965
Data associated genetically defective NK2 homeobox 6 (NKX2-6) with enhanced susceptibility to atrial fibrillation (AF). PMID: 25319568
Heterozygous mutations in Nkx2.6, p.V176M and p.K177X, were identified in 2 unrelated patients, one with tetralogy of Fallot and one with double outlet of right ventricle and ventricular septal defect. Increased vulnerability to TOF or DORV is discussed. PMID: 25195019
NKX2-6 plays a role in human cardiogenesis. PMID: 24421281
weakly activates transcription of a Cx40 promoter, may have role in heart development PMID: 15649947
NKX2.5/NKX2.6 mutations are not a common cause of isolated type 1 truncus arteriosus in a small cohort of multiethnic cases. PMID: 18939937

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Involvement in disease

Conotruncal heart malformations (CTHM)

Subcellular Location

Nucleus.

Protein Families

NK-2 homeobox family

Database Links

HGNC: 32940

OMIM: 217095

KEGG: hsa:137814

STRING: 9606.ENSP00000320089

UniGene: Hs.532654

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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