NR2E1 Antibody

1. ASK1 phosphorylated and stabilized TLX, which led induction of HIF-1alpha, and its downstream VEGF-A in an Akt dependent manner. PMID: 27890558
2. TLX and miR-219 have an important role in both normal neurodevelopment and in schizophrenia patient iPSC-derived NSCs. TLX has a role in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation. PMID: 26965827
3. TLX downregulation induces TET3 expression and inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells. PMID: 26838672
4. TLX has a role in regulating growth and invasion in ERalpha-negative breast cancer cells PMID: 26280373
5. TLX biological role in mental illness and gliomagenesis PMID: 26554934
6. Increased NR2E1 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients. PMID: 25813674
7. These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro PMID: 25327364
8. NR2E1 regulates CBX7 and restrains senescence in neural stem cells. PMID: 25328137
9. TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes PMID: 25557355
10. The effect of TLX on the proliferative, invasive and migratory properties of IMR-32 cells attributed to the recruitment of TLX to both MMP-2 and Oct-4 gene promoters, which resulted in the respective gene activation. PMID: 25356871
11. TLX is involved in interleukin (IL)-1beta-induced changes in adult hippocampal neurogenesis. PMID: 23510989
12. TLX/NR2E1 and related NRs such as PNR and COUPTFs can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates TLX-mediated repression of the RARb2 gene. PMID: 23975195
13. No mutations in the NR2E1 gene were found in aniridia patients. PMID: 23213277
14. Enriched expression of TLX in higher-grade human gliomas is observed. PMID: 23028043
15. BCL11A is a novel TLX coregulator that might be involved in TLX-dependent gene regulation in the brain. PMID: 22675500
16. Cerebrum and olfactory bulb hypoplasia, hallmarks of the Nr2e1-null mice phenotype, were not fully corrected in animals harboring one functional copy of human NR2E1. PMID: 22290436
17. Transgenic TLX acts as an essential regulator that ensures the proliferative ability of postnatal neural stem cells by controlling their activation through genetic interaction with p53 and other signaling pathways. PMID: 21957244
18. Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia. PMID: 21135096
19. Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression. PMID: 21368052
20. Increased TLX expression was observed in a number of glioma cells and glioma stem cells, and correlated with poor survival of patients with gliomas. PMID: 20814749
21. nuclear receptor tailless transcripts are overexpressed in human primary glioblastomas in which Tlx expression is restricted to a subpopulation of nestin-positive perivascular tumor cells PMID: 20360385
22. compared sequence from human, mouse, and the puffer fish Fugu rubripes PMID: 12079282
23. Transgenic human NR2E1 was sufficient to fix structural brain & eye abnormalities & hyperaggressiveness in mice deleted for mouse Nr2e1. NR2E1 protein & regulatory sequences are comparable between these species. PMID: 16000615
24. Strong purifying selection, low genetic diversity, 21 novel polymorphisms and five common haplotypes at were detected at NR2E1; protein-coding changes do not contribute to cortical and behavioral abnormalities, but regulatory mutations may play a role. PMID: 17054721
25. we cannot exclude the possibility that deletions at NR2E1 may underlie MMEP, given that sequencing is unable to distinguish between homozygosity across loci versus large deletions PMID: 17655765
26. TLX recruits histone deacetylases to repress transcription of p21(CIP1/WAF1) and pten and regulate neural stem cell proliferation PMID: 17873065
27. Genetic variation at NR2E1 may be associated with susceptibility to brain-behavior disorders. PMID: 18205168
28. LSD1 is a histone demethylase that is the prime corepressor for TLX PMID: 18391013
29. TLX is an inducer of SIRT1 and may contribute to neurogenesis both as a transactivator and as a repressor. PMID: 19555662

Show More

Hide All

HGNC: 7973

OMIM: 603849

KEGG: hsa:7101

STRING: 9606.ENSP00000357982

UniGene: Hs.157688