NRBF2 Antibody

Code CSB-PA822209DSR2HU
Size US$166
Order now
Image
  • Western blot
    All lanes: NRBF2 antibody at 5.51μg/ml
    Lane 1: HepG2 whole cell lysate
    Lane 2: A549 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 33, 27, 32 kDa
    Observed band size: 33 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA822209DSR2HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NRBF2 Polyclonal antibody
Uniprot No.
Target Names
NRBF2
Alternative Names
Comodulator of PPAR and RXR 1 antibody; Comodulator of PPAR and RXR 2 antibody; Comodulator of PPAR and RXR antibody; COPR antibody; COPR1 antibody; COPR2 antibody; DKFZp564C1664 antibody; FLJ30395 antibody; NRBF 2 antibody; NRBF-2 antibody; NRBF2 antibody; NRBF2_HUMAN antibody; Nuclear receptor binding factor 2 antibody; Nuclear receptor-binding factor 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nuclear receptor-binding factor 2 protein (10-220AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).; Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation.
Gene References into Functions
  1. Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure. PMID: 27385829
  2. This study reveals NRBF2 as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. PMID: 28059666
  3. Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1-ATG14 (human), were characterized. PMID: 27630019
  4. Polymorphisms in a putative enhancer at the 10q21.2 Breast Cancer Risk Locus regulate NRBF2 expression, implicating this gene in the etiology of breast cancer. PMID: 26073781
  5. Nrbf2 may interact with the Atg14L-containing Beclin 1-Vps34 protein complex to modulate protein-protein interactions within the complex. PMID: 25086043
  6. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. PMID: 24785657
  7. The activation domain, their small size (COPR1, 26.9 kDa; COPR2, 32.4 kDa), and strict dependence on AF-2 for interaction distinguish COPR1 and COPR2 from the SMRT/NCoR type of corepressor and may dampen rather than repress NR-mediated gene expression. PMID: 15610520

Show More

Hide All

Subcellular Location
Nucleus. Cytoplasm. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome.
Tissue Specificity
Detected in keratinocytes, liver and placenta. Expressed in a subset of cells in pediatric medulloblastoma.
Database Links

HGNC: 19692

OMIM: 616477

KEGG: hsa:29982

STRING: 9606.ENSP00000277746

UniGene: Hs.449628

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*