OSBPL2 Antibody

Datasheet

Code	CSB-PA884442LA01HU
Size	US$166
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Image	Western blot All lanes: OSBPL2 antibody at 1μg/ml Lane 1: HepG2 whole cell lysate Lane 2: Mouse heart tissue Lane 3: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 56, 54 kDa Observed band size: 56 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA884442LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) OSBPL2 Polyclonal antibody

Uniprot No.

Q9H1P3

Target Names

OSBPL2

Alternative Names

FLJ20223 antibody; KIAA0772 antibody; MGC4307 antibody; MGC8342 antibody; ORP-2 antibody; ORP2 antibody; OSBL2_HUMAN antibody; OSBP related protein 2 antibody; OSBP-related protein 2 antibody; OSBPL2 antibody; Oxysterol binding protein like 2 antibody; Oxysterol binding protein related protein 2 antibody; Oxysterol-binding protein-related protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Oxysterol-binding protein-related protein 2 protein (251-480AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The OSBPL2 Antibody (Product code: CSB-PA884442LA01HU) is Non-conjugated. For OSBPL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA884442LB01HU	OSBPL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA884442LC01HU	OSBPL2 Antibody, FITC conjugated
Biotin	CSB-PA884442LD01HU	OSBPL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).

Gene References into Functions

point at a novel function of ORP2 as a lipid-sensing regulator of the actin cytoskeleton, with impacts on hepatocellular migration, adhesion, and proliferation PMID: 29092904
this study identifies ORP2 as a new regulatory nexus of Akt signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation. PMID: 29947926
a novel role for ORP2 in regulating steroidogenic capacity and cholesterol homeostasis in the adrenal cortex PMID: 26992564
This study and the recent description of another frameshift mutation in a Chinese ADNSHL family identify OSBPL2 as a novel gene for progressive deafness. PMID: 25759012
Results identified frameshift and missense mutation in OSBPL2 gene in familial and sporadic case of deafness suggesting OSBPL2 as a novel candidate gene for autosomal dominant nonsyndromic hearing loss . PMID: 25077649
ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking. PMID: 11861666
Results identify ORP2 as a sterol receptor present on LD and provide evidence for its role in the regulation of neutral lipid metabolism, possibly as a factor that integrates the cellular metabolism of triglycerides with that of cholesterol. PMID: 19224871

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Involvement in disease

Deafness, autosomal dominant, 67 (DFNA67)

Subcellular Location

Cytoplasm, cytosol. Lipid droplet. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

OSBP family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 15761

OMIM: 606731

KEGG: hsa:9885

STRING: 9606.ENSP00000316649

UniGene: Hs.473254

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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