PAN2 Antibody

Datasheet

Code	CSB-PA681391LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA681391LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA681391LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PAN2 Polyclonal antibody

Uniprot No.

Q504Q3

Target Names

PAN2

Alternative Names

hPan2 antibody; Inactive ubiquitin carboxyl terminal hydrolase 52 antibody; Inactive ubiquitin carboxyl-terminal hydrolase 52 antibody; KIAA0710 antibody; PAB dependent poly(A) specific ribonuclease subunit 2 antibody; PAB-dependent poly(A)-specific ribonuclease subunit 2 antibody; PABP dependent poly(A) nuclease 2 antibody; PAN 2 antibody; PAN2 antibody; PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit antibody; PAN2 poly(A) specific ribonuclease subunit homolog antibody; PAN2 polyA specific ribonuclease subunit homolog antibody; PAN2_HUMAN antibody; Ubiquitin specific peptidase 52 antibody; Ubiquitin specific protease 52 antibody; USP 52 antibody; USP52 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human PAB-dependent poly(A)-specific ribonuclease subunit PAN2 protein (628-908AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PAN2 Antibody (Product code: CSB-PA681391LA01HU) is Non-conjugated. For PAN2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA681391LB01HU	PAN2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA681391LC01HU	PAN2 Antibody, FITC conjugated
Biotin	CSB-PA681391LD01HU	PAN2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.

Gene References into Functions

USP52 is a bona fide ubiquitin-specific protease, and USP52 promotes ASF1A deubiquitination and stabilization. PMID: 29599486
USP52 is a key component of P-bodies required to prevent HIF1A mRNA degradation PMID: 23398456
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
hPan2 and hPan3 have roles in mRNA decay and exhibit cytoplasmic co-localization PMID: 14583602

Subcellular Location

Cytoplasm. Cytoplasm, P-body. Nucleus.

Protein Families

Peptidase C19 family, PAN2 subfamily

Database Links

HGNC: 20074

OMIM: 617447

KEGG: hsa:9924

STRING: 9606.ENSP00000401721

UniGene: Hs.273397

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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