PAN2 Antibody, HRP conjugated

Datasheet

Code	CSB-PA681391LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PAN2 Polyclonal antibody

Uniprot No.

Q504Q3

Target Names

PAN2

Alternative Names

hPan2 antibody; Inactive ubiquitin carboxyl terminal hydrolase 52 antibody; Inactive ubiquitin carboxyl-terminal hydrolase 52 antibody; KIAA0710 antibody; PAB dependent poly(A) specific ribonuclease subunit 2 antibody; PAB-dependent poly(A)-specific ribonuclease subunit 2 antibody; PABP dependent poly(A) nuclease 2 antibody; PAN 2 antibody; PAN2 antibody; PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit antibody; PAN2 poly(A) specific ribonuclease subunit homolog antibody; PAN2 polyA specific ribonuclease subunit homolog antibody; PAN2_HUMAN antibody; Ubiquitin specific peptidase 52 antibody; Ubiquitin specific protease 52 antibody; USP 52 antibody; USP52 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human PAB-dependent poly(A)-specific ribonuclease subunit PAN2 protein (628-908AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.

Gene References into Functions

USP52 is a bona fide ubiquitin-specific protease, and USP52 promotes ASF1A deubiquitination and stabilization. PMID: 29599486
USP52 is a key component of P-bodies required to prevent HIF1A mRNA degradation PMID: 23398456
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
hPan2 and hPan3 have roles in mRNA decay and exhibit cytoplasmic co-localization PMID: 14583602

Subcellular Location

Cytoplasm. Cytoplasm, P-body. Nucleus.

Protein Families

Peptidase C19 family, PAN2 subfamily

Database Links

HGNC: 20074

OMIM: 617447

KEGG: hsa:9924

STRING: 9606.ENSP00000401721

UniGene: Hs.273397

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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