PAX1 Antibody

1. The association between PAX1 and the susceptibility of AIS was successfully replicated in the Chinese population PMID: 29095406
2. Hypermethylated ZNF582 and PAX1 genes in the oral scrapings collected from adjacent normal oral mucosal sites rather than cancer sites are associated with aggressive progression and poor prognosis of OSCC PMID: 29224816
3. A novel PAX1 null homozygous mutation in autosomal recessive otofaciocervical syndrome associated with severe combined immunodeficiency has been described in a consanguineous family. PMID: 28657137
4. PAX1 gene methylation was associated with the transition of CIN I to CIN II/III and CIN II/III to cervical cancer, so that it could be an auxiliary biomarker to estimate the risk of CIN progress. PMID: 28472814
5. conclude that hypermethylated ZNF582 and PAX1 are effective biomarkers for the detection of oral dysplasia and oral cancer and for the prediction of oral cancer recurrence PMID: 27865370
6. DNA methylation status of PAX1 showed a relatively good sensitivity and specificity for the detection of ESOPHAGEAL SQUAMOUS CELL CARCINOMA. PMID: 28241446
7. Paired boxed gene 1 protein expression is a potential histopathology biomarker for the differential diagnosis of malignant and premalignant endometrial lesions. Paired boxed gene 1 is also a potential prognostic marker in cases of endometrial carcinoma. PMID: 27226215
8. Hypermethylation of PAX1 gene may be highly associated with the development of cervical cancer. PMID: 26552048
9. meta-analysis support the utility of PAX1 methylation as an auxiliary biomarker in cervical cancer screening PMID: 26234429
10. Testing PAX1 DNA methylation using oral swabs is a promising method for oral cancer detection. Combined assessments regarding betel nut consumption and DNA methylation can improve OSCC screening PMID: 23907469
11. PAX1 methylation hallmarks a potential diagnostic value for cervical cancer screening in Asians PMID: 26642709
12. analysis of a PAX1 enhancer locus that is associated with susceptibility to idiopathic scoliosis in females PMID: 25784220
13. PAX1 and SOX1 DNA methylation correlate with a cervical intraepithelial neoplasia diagnosis. PMID: 24799352
14. PAX1 methylation is associated with cervical cancer. PMID: 24844223
15. PAX1 methylation is associated with high-grade squamous intraepithelial lesions. PMID: 24568514
16. Cervical adenocarcinoma cells carry aberrantly high methylation rates of PAX1, commonly methylated in squamous cell carcinomas. PMID: 24407576
17. We identified PAX1 as a novel disease-causing gene for otofaciocervical syndrome and show that the pooling of DNA from affected individuals can reduce the number of putative disease-causing homozygous variants in consanguineous families. PMID: 23851939
18. PAX1 hypermethylation is associated with cervical cancer. PMID: 20442585
19. There was a significant reduction in PAX1 expression in fetuses with the Jarcho-Levin syndrome. PMID: 12833407
20. No mutations were identified in the PAX1 and MEOX1 exons or flanking intronic sequences, excluding them as likely causative genes for diaphanospondylodysostosis PMID: 17764081

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HGNC: 8615

OMIM: 167411

KEGG: hsa:5075

STRING: 9606.ENSP00000381499

UniGene: Hs.122310