PCDH1 Antibody

Datasheet

Code	CSB-PA2106ESR2HU
Size	US$166
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Image	Western blot All lanes: PCDH1 antibody at 2.56μg/ml Lane 1: A431 whole cell lysate Lane 2: Human breast cancer cell Lane 3: Jurkat whole cell lysate Lane 4: Hela whole cell lysate Lane 5: NIH/3T3 whole cell lysate Lane 6: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 115, 134 kDa Observed band size: 115 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA2106ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA2106ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PCDH1 Polyclonal antibody

Uniprot No.

Q08174

Target Names

PCDH1

Alternative Names

Cadherin like 1 antibody; Cadherin like protein 1 antibody; Cadherin-like protein 1 antibody; FLJ53887 antibody; MGC45991 antibody; OTTHUMP00000160067 antibody; PC 42 antibody; PC42 antibody; PCDH 1 antibody; PCDH 42 antibody; PCDH1 antibody; PCDH1_HUMAN antibody; PCDH42 antibody; Protocadherin 1 antibody; Protocadherin 42 antibody; Protocadherin-1 antibody; Protocadherin-42 antibody; Protocadherin1 antibody; Protocadherin42 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Protocadherin-1 protein (60-220AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May be involved in cell-cell interaction processes and in cell adhesion.

Gene References into Functions

Results show that PCDH1 is localized to the cell membrane of bronchial epithelial cells basolateral to the adherens junction. Its expression is not reduced nor delocalized in asthma even though PCDH1 contributes to homotypic adhesion, epithelial barrier formation and repair. PMID: 27701444
PCDH1 is important for airway function as a physical barrier, and its dysfunction is involved in the pathogenesis of allergic airway inflammation. PMID: 26227965
PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects sensitivity of the airway epithelium to TGF-beta. PMID: 26209277
Common variations in PCDH1 increase the risk of developing both transient early asthma and atopic dermatitis in early childhood PMID: 23988763
genetic polymorphism is associated with subphenotypes of asthma in German children PMID: 23050600
PCDH1 gene variant IVS3-116 associates with eczema in two independent birth cohorts in Netherlands. PMID: 21929597
PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains; enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells. PMID: 21982948
PCDH1 is a novel gene for BHR in adults and children. Its identification as a BHR susceptibility gene may suggest that a structural defect in the integrity of the airway epithelium and contributes to the development of BHR. PMID: 19729670

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Subcellular Location

Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.

Tissue Specificity

Highly expressed in the brain and neuro-glial cells.

Database Links

HGNC: 8655

OMIM: 603626

KEGG: hsa:5097

STRING: 9606.ENSP00000287008

UniGene: Hs.79769

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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