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PGD Antibody

Datasheet
Code CSB-PA01155A0Rb
Size US$166
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Image
  • Western Blotting(WB) - PGD Antibody
    Western blot
    All lanes: PGD antibody at 2µg/ml
    Lane 1: EC109 whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 54, 52 kDa
    Observed band size: 54 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PGD Polyclonal antibody
Uniprot No.
P52209
Target Names
PGD
Alternative Names
0610042A05Rik antibody; 6 phosphogluconate dehydrogenase; decarboxylating antibody; 6-phosphogluconate dehydrogenase antibody; 6PGD antibody; 6PGD_HUMAN antibody; AU019875 antibody; C78335 antibody; decarboxylating antibody; OTTMUSP00000011754 antibody; Pgd antibody; Phosphogluconate dehydrogenase antibody; RP23-249G3.4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 6-phosphogluconate dehydrogenase, decarboxylating protein (4-483AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PGD Antibody (Product code: CSB-PA01155A0Rb) is Non-conjugated. For PGD Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA01155B0Rb PGD Antibody, HRP conjugated ELISA
FITC CSB-PA01155C0Rb PGD Antibody, FITC conjugated
Biotin CSB-PA01155D0Rb PGD Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

PGD Antibodies

PGD Proteins

Customer Reviews and Q&A

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Target Background

Function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Gene References into Functions
  1. identified that 6-phosphogluconate dehydrogenase (6PGD) is critically involved in the development of anaplastic thyroid cancer (ATC) resistance to doxorubicin. 6PGD inhibition disrupts metabolic reprogramming in doxorubicin-resistant ATC cells. PMID: 29534964
  2. Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1-AMPK signalling. PMID: 26479318
  3. copy number gain of the PGD gene was consistently identified in cervical cancers but not in the normal tissues PMID: 24125036
  4. Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells. PMID: 25042803
  5. Expression of 6PGD positively correlates with advancing stage of lung carcinoma. Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation. PMID: 23973484
  6. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence PMID: 22677172
  7. Data suggest that the affinity of Nox2 for NADPH is increased in the presence of 6PGDH on cell stimulation. PMID: 21444627
  8. Hsa-miR-132 and -212 were negatively correlated with PGD in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. PMID: 20675101

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Subcellular Location
Cytoplasm.
Protein Families
6-phosphogluconate dehydrogenase family
Database Links

HGNC: 8891

OMIM: 172200

KEGG: hsa:5226

STRING: 9606.ENSP00000270776

UniGene: Hs.464071

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