POFUT2 Antibody

Code CSB-PA018297GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
POFUT2
Alternative Names
POFUT2 antibody; C21orf80 antibody; FUT13 antibody; KIAA0958 antibody; GDP-fucose protein O-fucosyltransferase 2 antibody; EC 2.4.1.221 antibody; Peptide-O-fucosyltransferase 2 antibody; O-FucT-2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human POFUT2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.
Gene References into Functions
  1. This study demonstrated that the alteration of POFUT2 expression in the superior temporal gyrus of elderly patients with schizophrenia. PMID: 27773385
  2. POFUT2 and B3GLCT mediate a noncanonical endoplasmic reticulum quality-control mechanism that recognizes folded thrombospondin type 1 repeats and stabilizes them by glycosylation. PMID: 25544610
  3. Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation. PMID: 22588082
Subcellular Location
Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum.
Protein Families
Glycosyltransferase 68 family
Tissue Specificity
Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liv
Database Links

HGNC: 14683

OMIM: 610249

KEGG: hsa:23275

STRING: 9606.ENSP00000339613

UniGene: Hs.592164

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