POLR1E Antibody

Code CSB-PA050039
Size US$119
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Product Details

Uniprot No.
Target Names
POLR1E
Alternative Names
A49 antibody; DNA directed RNA polymerase I subunit RPA49 antibody; DNA-directed RNA polymerase I subunit E antibody; DNA-directed RNA polymerase I subunit RPA49 antibody; FLJ 13390 antibody; FLJ13970 antibody; PAF53 antibody; POLR 1 E antibody; POLR1E antibody; Polymerase (RNA) I associated factor 1 antibody; Polymerase (RNA) I polypeptide E antibody; Polymerase (RNA) I polypeptide E, 53kDa antibody; PRAF1 antibody; RNA polymerase I associated factor 1 antibody; RNA polymerase I associated factor 53 antibody; RNA polymerase I polypeptide E antibody; RNA polymerase I subunit A49 antibody; RNA polymerase I-associated factor 1 antibody; RNA polymerase I-associated factor 53 antibody; RP11405L18.3 antibody; RPA49_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human POLR1E.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.
Gene References into Functions
  1. Nucleolar detention requires binding of SIRT7 to nascent pre-rRNA, linking the spatial distribution of SIRT7 and deacetylation of PAF53 to ongoing transcription. PMID: 24207024
Subcellular Location
Nucleus, nucleolus.
Protein Families
Eukaryotic RPA49/POLR1E RNA polymerase subunit family
Database Links

HGNC: 17631

KEGG: hsa:64425

STRING: 9606.ENSP00000367029

UniGene: Hs.591087

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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